Semaglutide for Your Weight Loss Journey

Semaglutide is usually taken once a week, with the dose increased gradually over time. Many people begin with:

• 0.25 mg once weekly for the first 4 weeks to help the body adjust
• 0.5 mg once weekly after the starting phase
• 1 mg once weekly if additional support is needed and your provider decides it is appropriate

Dose changes depend on how your body responds, how well you tolerate semaglutide, and your provider's treatment plan.

Semaglutide is injected under the skin once weekly, ideally on the same day each week. It can be used with or without food.

• Inject semaglutide into the stomach area, thigh, or upper arm
• Choose a different injection spot each week to avoid using the same area repeatedly
• Do not inject semaglutide into a vein or muscle
• Check the medication before injecting it. The solution should look clear and colorless

The most common semaglutide side effects affect the digestive system. They are more likely to happen when the dose is increased and may ease as your body gets used to the medication.

Common side effects may include:

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Stomach pain or discomfort
• Indigestion
• Reduced appetite
• Fatigue
• Dizziness

Although less common, semaglutide may also cause more serious side effects, including pancreatitis, gallbladder problems, kidney issues linked to dehydration, worsening diabetic retinopathy in people who already have the condition, and rare allergic reactions. Contact a healthcare provider if side effects are severe, ongoing, or concerning.

Semaglutide slows how quickly food leaves the stomach, which may change how some oral medications are absorbed. It may also need extra caution when used with medications that affect blood sugar, heart rate, or heart rhythm.

Use caution with:

• Medications that may increase heart rate
• Drugs that prolong the PR interval, including some antiarrhythmics, beta blockers, calcium channel blockers, digitalis glycosides, and certain HIV medications
• Warfarin and other coumarin-based blood thinners, since INR levels may change when starting Semaglutide

Before starting semaglutide, tell your doctor or pharmacist about all medications you take, including prescription drugs, over-the-counter medicines, vitamins, and supplements. This helps them check for possible interactions and decide whether semaglutide is safe for you.